Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes

Retrieved on: 2024-09-19 22:26:27

Tags for this article:

Posttranslational modification

Proteins

Tyrosine kinase receptors

Ubiquitin ligase

PTPN11

Hepatocyte growth factor receptor

Von Hippel–Lindau tumor suppressor

Ubiquitin

Proteolysis targeting chimera

Proteasome

Ras GTPase

Small interfering RNA

Click the tags to see associated articles and topics

Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes. View article details on hiswai:

Excerpt

For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a 'biological Proteolysis-Targeting Chimera' (bioPROTAC) ...

Article found on: www.nature.com

View Original Article